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Researchers studying receptor desensitization also use paired GHRH/GHS protocols to compare downregulation kinetics against single-agent controls, since repeated stimulation of the GHRH receptor alone can blunt responsiveness over time in ways that combined signaling may partially offset

This happens through the aptly named "glutathione-ascorbic acid cycle." In another observational study, individuals with lower levels of vitamin C also had insufficient levels of glutathione, hinting at the symbiotic connection between the two